The calories in a can of fruit cocktail varies with the size. A small can typically ranges between 40 to 60 calories per serving. If it's a light brand, then the calories are a lot lower. Larger cans range between 76 to 260 calories. The difference in calories depends on whether or not the fruit is canned in water, syrup or juice. Water and juice are healthier and better for you. Syrup may be light or heavy and changes the calorie content drastically. It has a great deal of sugar, corn starches and preservatives that change the dietary content. It's suggested to eat this brand in moderation or not at all.